Human Herpesvirus 6 Genome and Antigen in Acute Multiple Sclerosis Lesions
نویسندگان
چکیده
منابع مشابه
Multiple sclerosis and human herpesvirus 6.
BACKGROUND A possible but as yet unproven relationship has been proposed between the onset or persistence of multiple sclerosis (MS) symptoms and herpesviruses, including, most recently, human herpesvirus 6 (HHV-6). A study was conducted to investigate the presence of HHV-6 DNA and the synthesis of antibodies against HHV-6, cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in serum and cerebro...
متن کاملHuman herpesvirus 6 in multiple sclerosis and encephalitis
Human herpesvirus 6 (HHV-6) was identified from patients with HIV and lymphoproliferative diseases in 1986. It is a β-herpesvirus and is divided into two subgroups, variants A and B. HHV-6 variant B is the cause of exanthema subitum, while variant A has not yet definitely proven to cause any disease. HHV-6, especially variant A, is a highly neurotropic virus and has been associated with many di...
متن کاملHuman herpesvirus 6 and multiple sclerosis: the continuing conundrum.
Human herpesvirus 6 (HHV-6) is one of the latest in a long list of infectious agents postulated to play a role in the etiopatho-genesis of multiple sclerosis (MS). It is essential in critically evaluating the still exceedingly controversial association between MS and HHV-6 to understand the basic biology of the virus. HHV-6 was first isolated in 1986 from human peripheral blood mononuclear cell...
متن کاملRelapsing-remitting multiple sclerosis and human herpesvirus 6 active infection.
BACKGROUND Recent studies have focused on the relationship between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS). OBJECTIVE To analyze HHV-6 messenger RNA expression in patients with relapsing-remitting (RR) MS vs healthy blood donors (HBDs). DESIGN One hundred fifty-four subjects were enrolled in the study: 105 patients with RRMS (32 in relapse) and 49 HBDs. Total DNA and messeng...
متن کاملActive human herpesvirus 6 infection in patients with multiple sclerosis.
CONTEXT Human herpesvirus 6 (HHV-6) has been linked with multiple sclerosis (MS). OBJECTIVES To determine HHV-6 viral load in patients with MS, and to analyze separately its 2 variants, HHV-6A and HHV-6B. PATIENTS AND METHODS We analyzed 149 blood and serum samples; 103 were from patients with relapsing-remitting MS (33 during an MS relapse and 70 during remission), and 46 were from healthy...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2003
ISSN: 0022-1899,1537-6613
DOI: 10.1086/368172